Bis(azolyl)sulfonamidoacetamides: Synthesis and bioassay

Azole derivatives are valuable precursors in pharmacological arena. In fact, oxazole, thiazole and imidazole containing scaffolds display a variety of biological activities such as antitumor,1 antibacterial,2 antiviral,3 antioxidant,4,5 anti-inflammatory6 antifungal7 activities. Azoles also prominant molecules various biochemical synthetic transformations. Based on the importance these heteroaromatics our interest to link heterocycle with functional groups we have synthesized new class bis(azolyl)sulfonamide acetamides from azolylsulfonylamines azolylchloroacetamides presence DMAP under ultrasonication studied their antimicrobial activity. The compounds chloro substituted bis(thiazoles) (6c) imidazolyl thiazoles (7c) displayed excellent antibacterial activity against B. subtilis greater than standard drug, Chloramphenicol. Whereas 7c showed antifungal A. niger higher Ketoconazole.